一、个人简介

华南师范大学 研究员、博士生导师

针对国家在疾病快速准确诊断筛查方面的战略需求，胡家铭教授长期致力于高特异性分子诊断和生物芯片领域的研究，围绕当前社会急需的疾病早期检测领域开展研究工作，从化学、生物、材料和物理多学科交叉角度，围绕基于多通道光信号、电信号的核酸检测和蛋白检测来实现对疾病的体外诊断，尤其对癌症的早期诊断。胡家铭教授在Nat. Commun., Chem, JACS, Biomaterials等SCI期刊上发表论文20余篇，以第一发明人和申请人申请美国发明专利3项（1项已授权），中国发明专利1项，获美国陶氏化学奖、英国皇家化学会新兴领域开拓者称号等多项国际荣誉及奖项。

二、学习工作经历

2018-至今  华南师范大学，bat365官网登录，研究员

2015-2018  美国俄亥俄州立大学，化学与生物分子工程学院，博士后

2013-2014  美国BioLegend, Inc.，生物标志物开发部，产品开发首席科学家

2008-2013  美国奥本大学，化学系，分析化学，博士

2006-2008  同济大学，化学系，分子科学实验室，研究助理

2002-2006  同济大学，化学系，应用化学，学士

三、学术任职

兼任多个SCI期刊编委和审稿人

招聘信息

招博士后及青年英才，研究方向包括但不限于：单细胞/外泌体分析芯片技术、生物医用纳米材料、分子影像探针、肿瘤靶向诊断与治疗、肿瘤细胞基因检测技术等。

1.  Sheng, Y.; Zhang, T.; Zhang, S.; Johnston, M.; Zheng, X.; Shan, Y.; Liu, T.; Huang, Z.; Qian, F.; Xie, Z.; Ai, Y.; Zhong, H.; Kuang, T.*; Dincer, C.*; Urban, G.; Hu, J.* A CRISPR/Cas13a-powered catalytic electrochemical biosensor for successive and highly sensitive RNA diagnostics. Biosensors and Bioelectronics 2021, 178, 117.

2.   Shen, J.; Zhou, X.; Shan, Y.; Yue, H.; Huang, R.; Hu, J.*; Xing, D.* Sensitive detection of a bacterial pathogen using allosteric probe-initiated catalysis and CRISPR-Cas13a amplification reaction. Nature Communications 2020, 11, 267.

3.      Hu, J.*; Kwak, K. J.; Shi, J.; Yu, B.; Sheng, Y.; Lee, L. J. Overhang molecular beacons encapsulated in tethered cationic lipoplex nanoparticles for detection of single-point mutation in extracellular vesicle-associated RNAs. Biomaterials 2018, 183, 20-29.

4.      Hu, J.*; Kuang, T. DNA-Coded Fluorescence for Color Painting RNAs. Chem 2018, 4, 1194-1196.

5.      Hu, J.*; Sheng, Y.; Kwak, K. J.; Shi, J.; Yu, B.; Lee, L. J. A signal-amplifiable biochip quantifies extracellular vesicle-associated RNAs for early cancer detection. Nature Communications 2017, 8, 1683.

6.      Hu, J.; Yu, Y.; Brooks, J. C.; Godwin, L. A.; Somasundaram, S.; Torabinejad, F.; Kim, J.; Shannon, C.; Easley, C. J. A Reusable Electrochemical Proximity Assay for Highly Selective, Real-Time Protein Quantitation in Biological Matrices. J. Am. Chem. Soc. 2014, 136, 8467-8474.

7.      Hu, J.; Wang, T.; Kim, J.; Shannon, C.; Easley, C. J. Quantitation of Femtomolar Protein Levels via Direct Readout with the Electrochemical Proximity Assay. J. Am. Chem. Soc. 2012, 134, 7066-7072.

8.      Chang, L.; Hu, J.†; Chen, F.; Chen, Z.; Shi, J.; Yang, Z.; Li, Y.; Lee, L. J. Nanoscale Bio-Platforms for Living Cell Interrogation: Current Status and Future Perspectives. Nanoscale 2015.

9.      Hu, J.; Sheng, Y.; Shi, J.; Yu, B.; Yu, Z.; Liao, G. Long Circulating Polymeric Nanoparticles for Gene/Drug Delivery. Current Drug Metabolism 2018, 19, 723-738.

10.    Sheng, Y.; Hu, J.†; Shi, J.; Lee, L. J. Stimuli-responsive carriers for controlled intracellular drug release. Curr Med Chem 2019, 26, 2377-2388.

11.    Hu, J.; Easley, C. J. A simple and rapid approach for measurement of dissociation constants of DNA aptamers against proteins and small molecules via automated microchip electrophoresis. Analyst 2011, 136, 3461-3468.

12.    Kim, J.; Hu, J.; Sollie, R. S.; Easley, C. J. Improvement of Sensitivity and Dynamic Range in Proximity Ligation Assays by Asymmetric Connector Hybridization. Anal. Chem. 2010, 82, 6976-6982.

13.    Sheng, Y.; Chang, L.; Kuang, T.; Hu, J. PEG/heparin-decorated lipid-polymer hybrid nanoparticles for long-circulating drug delivery. RSC Advances 2016, 6, 23279-23287.

14.    Sun, B.; Hu, J.; Yao, J.; Ji, S. a new multiplex solution for cytokine and chemokine quantification in biological samples. Cytokine 2014, 70, 49.

15.    Sun, B.; Hu, J.; Yao, J.; Ji, S. New multiplex assay panels for simultaneous quantification of major proinflammatory chemokines in human and mouse samples (TECH1P.866). The Journal of Immunology 2014, 192, 69.34.

16.    Yang, J.; Hu, J.* Aptamer-functionalized nanoparticles for targeted drug delivery in cancer therapy. European Journal Of BioMedical Research 2015, 1, 17-24.

17.    Chen, Z.; Wu, C.; Yang, Y.; Shi, J.; Hu, J.*; Yang, Z.; Chen, Z. Synthesis and drug delivery of mesoporous silica nanoparticles for cancer therapy. European Journal Of BioMedical Research 2015, 1, 30-36.

18.    Chang, L.; Chen, F.; Zhang, X.; Kuang, T.; Li, M.; Hu, J.; Shi, J.; Lee, L. J.; Cheng, H.; Li, Y. Synthetic Melanin E-Ink. ACS Applied Materials & Interfaces 2017, 9, 16553-16560.

19.    Chen, Z.; Chen, Z.; Yang, Z.; Hu, J.; Yang, Y.; Chang, L.; Lee, L. J.; Xu, T. Preparation and characterization of vacuum insulation panels with super-stratified glass fiber core material. Energy 2015, 93, Part 1, 945-954.

20.    Chen, Z.; Chen, Z.; Zhang, A.; Hu, J.; Wang, X.; Yang, Z. Electrospun nanofibers for cancer diagnosis and therapy. Biomaterials Science 2016, 4, 922-932.

21.    Chen, Z.; Cong, M.; Hu, J.; Yang, Z.; Chen, Z. Preparation of Functionalized TiO2 Nanotube Arrays and Their Applications. Science of Advanced Materials 2016, 8, 1231-1241.

发明专利

J Hu, T Wang, CJ Easley, CG Shannon.  Electrochemical proximity assay, US Patent 9,335,292, 2016

J Hu, Y Sheng, LJ Lee. Lipid-polymer Hybrid Nanoparticle Biochip and Application Thereof, US Patent App. 15/831,998, 2018

LJ Lee, J Hu, Y Sheng. Highly Stable and Specific Molecular Beacons Encapsulated in Cationic Lipoplex Nanoparticles and Application Thereof, US Patent App. 15/880,309, 2018